Premium
Western diet increases wheel running in mice selectively bred for high voluntary wheel running
Author(s) -
Garland Theodore,
Meek Thomas H,
Eisenmann Joey C
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.805.2
Subject(s) - wheel running , weaning , zoology , turnover , western diet , obesity , body weight , medicine , biology , endocrinology , management , economics
Mice from a long‐term breeding selective experiment for high wheel running offer a unique model to examine contributions of genetic and environmental factors in determining aspects of behavior and metabolism relevant to body‐weight regulation and obesity. Since generation 16 and continuing through 52, mice from the 4 replicate high runner (HR) lines have run 2.5–3‐fold more revs/day as compared with 4 non‐selected control (C) lines, but the nature of this selection limit is not understood. Wheel running, food consumption (Teklad Rodent Diet (W) 8604, 14% kJ from fat, or Harlan Teklad TD.88137 Western Diet, 42% kJ from fat, plus added sucrose), and body mass were measured every 1–2 weeks in 100 males for 2 months starting 3 days after weaning. Western diet (WD) was obesogenic for both HR and C, increasing body and retroperitoneal fat pad mass, the latter even controlling statistically for running distance and caloric intake. HR mice had less fat than C, explainable statistically by their greater running. Adjusting for body mass, HR had higher caloric intake than C, also explainable by their higher running. WD had little effect on running in C, but increased revs/day by up to 75% in HR. The remarkable stimulation of voluntary running by Western diet in HR mice may involve fuel usage during prolonged endurance exercise and/or direct behavioral effects on motivation. Supported by MSU Seed Grant to JCE and NSF IOB‐0543429 to TG.