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Habitual exercise is associated with reduced arterial stiffness in systemic lupus erythematosus
Author(s) -
Barnes Jill Nicole,
Nualnim Nantinee,
Sugawara Jun,
Tanaka Hirofumi
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.804.7
Subject(s) - medicine , arterial stiffness , systemic inflammation , population , cardiology , inflammation , pathogenesis , compliance (psychology) , blood pressure , psychology , social psychology , environmental health
Chronic, systemic inflammation has been implicated in the pathogenesis of cardiovascular disease and a potential underlying mechanism for vascular dysfunction often seen in individuals with systemic lupus erythematosus (SLE). Currently, it is unknown whether the favorable effect of habitual exercise observed in healthy adults can be extended to individuals with SLE. As an initial step to address this, we performed a cross‐sectional study to determine the association between habitual exercise, inflammatory markers, and arterial stiffness. We studied 41 adults, aged 33±11yr (15 healthy controls, 12 sedentary SLE, 14 exercising SLE). Age, BMI, and metabolic risk factors were not different between the 3 groups. Carotid arterial compliance was lower, and augmentation index and inflammatory markers (CRP, IL‐12, TNF‐α) were higher in sedentary SLE patients compared with healthy controls, but were not different between exercising SLE patients and healthy controls. In the pooled population, carotid arterial compliance was inversely associated with TNF‐α (p<0.01), and augmentation index was positively associated with CRP and ICAM‐1 (both p<0.05). These results indicate that habitual exercise is associated with a favorable effect on central arterial stiffness in individuals with SLE and the beneficial results may be mediated by the effect on inflammatory markers.