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Electrocortical activity response to intermittent transient tracheal occlusion
Author(s) -
Hotchkiss Mark T,
Hooker Jodi,
Adams Sherry,
Pate Kathryn,
Davenport Paul W
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.799.22
Subject(s) - wakefulness , anesthesia , arousal , occlusion , medicine , audiology , electroencephalography , psychology , cardiology , neuroscience , psychiatry
Respiratory loads elicit mechanosensation in conscious humans and animals. Intermittent transient tracheal occlusion (ITTO) produces an observable change in the attentive state of rats. We hypothesized that ITTO would produce a significant frequency power shift in electrocorticogram (ECoG) activity. The relative power of ECoG frequency ranges associated with relaxed wakefulness and sleep were expected to decrease: Delta (0.8–4.5 Hz), Theta (4.75–6.75 Hz), and Alpha (7.00–12.50 Hz). An increase in relative power was expected for frequency ranges associated with attentive wakefulness and perception: Beta (12.75–35 Hz), Gamma (35.25–100.00 Hz), and UHF (100.25 Hz and up). Rats were instrumented with electrodes on the surface of the cortex and an inflatable occluder was sutured around the trachea. Following post‐surgical recovery, the tracheal cuff was inflated to obstruct 3–10 breaths, and then deflated for a minimum of 15 breaths. The obstruction cycle was repeated for 15–20 minutes once each day for 10 days. Results of this study demonstrated the expected changes in ECoG frequency power associated with increased arousal. These results support the use of this model to study airway obstruction‐related arousal in unanesthetized rats.