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The magnitude of the hypoxic ventilatory response and ventilatory long‐term facilitation are reduced during sleep when compared to wakefulness
Author(s) -
Gerst D. G.,
Syed Z.,
Yokhana S. S.,
Lin H. S.,
Mateika J. H.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.799.13
Subject(s) - wakefulness , anesthesia , medicine , ventilation (architecture) , facilitation , sleep (system call) , psychology , electroencephalography , neuroscience , mechanical engineering , psychiatry , computer science , engineering , operating system
Purpose To determine the impact of arousal state on the magnitude of the hypoxic ventilatory response (HVR − Δ V E /Δ SaO 2 ) and ventilatory long‐term facilitation (vLTF). Methods 5 healthy male subjects were exposed to IH on two occasions. The IH protocol consisted of 12‐2 minute episodes of hypoxia (P ET O 2 – 50 mmHg) in the presence of P ET CO 2 levels sustained 3 mmHg above baseline. Each episode was followed by a 2 minute normoxic recovery period with the exception of the last recovery period which was 30 minutes in duration. One IH trial was completed during wakefulness, with the other completed during sleep. Results The HVR was greater during wakefulness compared to sleep in all participants (0.8 ± 0.2 vs. 0.5 ± 0.1 L/min/% SaO 2 , p = 0.06). Moreover, minute ventilation was greater during recovery compared to baseline, during both wakefulness and sleep (Wakefulness – 22.5 ± 1.8 vs. 18.6 ± 1.5 L/min, p = 0.03; Sleep – 15.2 ± 1.8 vs. 14.3 ± 1.8 L/min, p = 0.02). However, the magnitude of vLTF when standardized to baseline was significantly greater during wakefulness compared to sleep (1.21 ± 0.07 vs. 1.07 ± 0.02, p = 0.05). Conclusions Exposure to IH elicits vLTF during both wakefulness and sleep. However, the magnitude of the HVR and vLTF is significantly reduced during sleep compared to wakefulness. Funding: VA‐Merit Award