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The Effect of 28 days Administration of Betaine on Blood Pressure and Arteriolar Contractility in Normal and Spontaneously Hypertensive Rats.
Author(s) -
AlHusseini Isehaq Saif,
Albarwani Sulayma,
Ali Baderldin H,
Tanira Musbah O
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.786.23
Subject(s) - betaine , contractility , homocysteine , phenylephrine , blood pressure , isometric exercise , medicine , endocrinology , mesenteric arteries , chemistry , artery , biochemistry
Homocysteine, a possible risk factor of cardiovascular disease, may play a role in the pathogenesis of essential hypertension. Betaine serves as a methyl donor in a reaction converting homocysteine to methaionine. Previous studies showed, equivocally, that betaine could reduce blood pressure (bp) and blood homocysteine level. The aim of this study was to examine the effect of administering betaine on normal and spontaneously‐hypertensive rats (SHR) bp and aretiolar contractility. Male SHR and WKY rats weighing 180–230 g were used. They were divided into 7 groups and treated (i.p.) for 28 days as follows: control (normal saline) or betaine (0.4, 2, 10, 50, 100, 250mg/kg/day). Non invasive blood pressure measurement was taken weekly and small mesenteric arteries were used for the isometric study in which KCl, acetylcholine 5HT and phenylephrine were used as reference drugs. Betaine did not show any significant changes on bp or on the isometric studies. It may be concluded that under our experimental condition, betaine had no significant beneficial effect on tested parameters.