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Arterial Pressure Wave Reflection Site Shifts Periphery with Aging
Author(s) -
Sugawara Jun,
Hayashi Koichiro,
Tanaka Hirofumi
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.786.20
Subject(s) - pulse wave velocity , reflection (computer programming) , blood pressure , pulse pressure , cardiology , pulse (music) , medicine , aortic pressure , femoral artery , aorta , physics , optics , detector , computer science , programming language
Early return of reflection wave from the periphery to the heart relates to the augmentation of central pulse pressure, a risk for cardiovascular disease. We determined the impact of aging on the location of a major reflection site which would directly affect the timing of the reflected wave. Arterial length (via 3‐D artery tracing of MRI) and carotid‐femoral pulse wave velocity (PWV) were measured in 218 adults. Aortic blood pressure was estimated via the radial pressure waveform analysis. The major reflection site was detected by carotid‐femoral PWV and the time of return of the reflected wave (Δt) (via carotid pressure waveform analysis). The major reflection sites were located at abdominal aorta (e.g., proximally to aortic bifurcation) in most of subjects (82%). The length from heart to the major reflection site (L ref ) gradually increased with aging (r=0.53). Multi‐regression analyses revealed that L ref was significant independent determinant of aortic systolic and pulse pressure (β=−0.24 and β=−0.19). These results suggest that the major reflection site shifts periphery with aging, and that such age‐related shift of reflection site may partly attenuate the augmentation of central pulse pressure.