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Chronic placental ischemia decreases insulin‐like growth factor‐1 during late gestation in the rat
Author(s) -
Bozadjieva Nadejda Ivanova,
Soldner Emma L B,
Heltemes Alaina,
Gingery Anne,
Gilbert Jeffrey S
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.786.14
Subject(s) - preeclampsia , medicine , gestation , endocrinology , pregnancy , intrauterine growth restriction , perfusion , ischemia , fetus , placenta , placentation , biology , genetics
Preeclampsia and other pregnancy related hypertensive disorders affect ~ 8 % of all pregnancies and are a major source of maternal and neonatal morbidity and mortality. Although previous research indicates insulin‐like growth factor‐1 (IGF‐1) and its binding proteins (IGFBP) are important in preeclampsia and intrauterine growth restriction (IUGR), whether they are a cause or consequence of placental ischemia is unclear. We hypothesized that chronic placental ischemia during late pregnancy in the rat would reduce maternal levels of circulating IGF‐1 and IGFBP‐3. Rats were assigned to either reduced uteroplacental perfusion (RUPP; n=15) or normal pregnant control (NP; n=12) groups. RUPP was induced by placing silver clips on the abdominal aorta and ovarian arteries on day 14 of gestation. On day 19 of pregnancy, arterial pressure (124±4 vs. 106±2 mmHg; P<0.05) was increased in the RUPP vs. NP dams. Fetal (2.3±0.03 vs. 2.5±0.04g; P<0.05) and placental (0.42±0.01 vs. 0.46±0.01g; P<0.05) weights, plasma IGF‐1 concentrations (271.7 ± 16.1 vs. 325.6 ± 21.3 ng/mL; P<0.05) and serum IGFBP‐3 levels (0.12±0.07 vs. 0.29±0.02; P<0.05) were decreased in the RUPP vs. NP dams. These data identify an association between placental ischemia and the IGF system during pregnancy and support the hypothesis that placental ischemia results in decreased IGF‐1 and IGFBP‐3. Further, these data suggest that in addition to IUGR, IGF‐1 may play a role in placental ischemia‐induced hypertension.