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CARDIAC NORADRENALINE SPILLOVER IS NOT CORRELATED WITH HRV AND QT VARIABILITY IN PATIENTS WITH DEPRESSION AND PANIC DISORDER
Author(s) -
Nalivaiko Eugene,
Baumert Mathias,
Lambert Gavin,
Dawood Tye,
Lambert Elisabeth,
Esler Murray,
McGrane Mariee,
Barton David
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.782.5
Subject(s) - heart rate variability , detrended fluctuation analysis , medicine , cardiology , qt interval , heart rate , panic disorder , mathematics , blood pressure , anxiety , psychiatry , geometry , scaling
Relationship between heart rate variability (HRV) or QT variability and autonomic effects on the ventricular myocardium are unknown. To address these issues in the most direct way, we computed HRV and QT variability indices and correlated them with the amount of noradrenaline (NA) spillover from the heart. The study was performed in 17 subjects (12 with major depression disorder and 5 with panic disorder). Cardiac NA spillover was assessed using catheter technique coupled with isotope dilution. We compured standard HRV measures in the time and frequency domain (meanNN, SDNN, RMSSD, VLF, LF, HF, LF/HF ratio), and short‐term heart rate complexity was quantified using detrended fluctuation analysis, symbolic dynamics and sample entropy. QT variability was quantified using QT variability index, QT variance, rate‐corrected QT, QT/RR ratio, hysteresis of QT rate adaptation, global regression residual of the [QTi, RRi] fit, and QT/RR coherence. Overall, none of HRV indices, short‐term heart rate complexity indices, or QT interval variability indices correlated with cardiac NA spillover. We conclude that most currently available ECG‐derived indices do not reflect sympathetic influences in the myocardium.