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Studies on the Anti‐inflammatory, Antinociceptive and Antipyretics activities of extract from Leaves of Labisia pumila
Author(s) -
Ikujuni Catherine Moyinoluwa,
Okechukwu Patrick Nwabueze,
Rajagopal Mariani,
Panrengan Kumutamalar,
Akowuah Gabriel Akyirem
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.773.5
Subject(s) - carrageenan , licking , phytochemical , chemistry , traditional medicine , anti inflammatory , antipyretic , hot plate test , positive control , acetic acid , nociception , pharmacology , analgesic , medicine , food science , biochemistry , receptor
The dichloromethane (DCM) extract of Labisia pumila leaves were investigated for its anti‐inflammatory (acetic acid‐induced writhing and carrageenan‐induced paw oedema test), antinociceptive (hot‐plate and formalin test) and anti‐pyretics (yeast‐induced hyperpyrexia test) effects. The phytochemical screening of the extract was also investigated. In the anti‐inflammatory test, DCM extract (100 mg/kg) inhibited significantly the acetic acid‐induced writhing by 78.34% in relation to positive control (aspirin 100 mg/kg) value 88.93% ( p <0.05), while the carrageenan‐induced paw oedema was reduced by 50% in relation to positive control (indomethacin 10 mg/kg) value 38.24% ( p <0.05) in the experimental rat model. In the antinociceptive test, the extract (100 mg/kg) significantly reduced the licking time in both the early and late phases of the formalin test by 68.41 and 49.17%, in relation to positive control (morphine 5 mg/kg) value 75.17 and 100% ( p <0.01), respectively. The extract (100mg/kg) also showed significant effects on hot plate test by 48.75% ( p< 0.01). Treatment with DCM extract (100 mg/kg) showed a significant reduction in yeast‐induced pyrexia in the fourth hour by 5.4% in relation to positive control (aspirin 100 mg/kg) value 4.3% ( p< 0.01). Phytochemical screening of the extract indicated the presence of flavonoids, steroids and saponins. The present study confirmed that extracts from the leaves of L. pumila exhibited anti‐inflammatory, antinociceptive and anti‐pyretic activities and these effects might be due to the observed phytochemicals.