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Adolescent Maturation of D1 and D2 Dopamine Receptor Interactions
Author(s) -
Dwyer Jennifer Buenzle,
Martinez Lesly,
Ganddini Gabriela,
Perez Mayra,
Leslie Frances M
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.766.1
Subject(s) - dopamine receptor d2 , dopaminergic , neuroscience , dopamine , psychology , dopamine receptor d1 , amphetamine , dopamine receptor , population , medicine , environmental health
Adolescence is a developmental period during which neuropsychiatric disorders often emerge. This onset is likely influenced by the continued maturation of mesocorticolimbic dopamine (DA) systems. Consistent with this development, adolescents respond uniquely to drugs that target DA systems, with blunted behavioral responses to indirect agonists like amphetamine. We have previously shown using direct agonists, that the functional sensitivity of D1 and D2‐like receptors changes with age. To evaluate age differences in D1/D2 behavioral interactions, adolescent and adult rats were given combinations of second messenger‐selective direct D1 and D2 agonists. Drug‐induced locomotor and stereotypic behaviors were measured, and brains were collected for analysis of immediate early gene (IEG) expression via in situ hybridization for c‐fos and arc mRNA. Behavioral data suggests that D1/D2 interactions are immature during adolescence, as adults show synergistic behavioral responses to D1/D2 combinations while adolescents do not. IEG analysis suggests age differences in the neural circuitry underlying these behaviors. Interregional IEG correlation further suggests that dopaminergic drugs alter functional connectivity in the limbic system, with distinct effects in adolescence. These data have important implications for pharmacotherapy design and use in this population. Support: DA19138, PhRMA Foundation