Premium
A medical food and phytonutrient supplement improve cardiovascular disease risk factors in subjects with metabolic syndrome and elevated LDL
Author(s) -
Lerman Robert H,
Minich Deanna M,
Darland Gary,
Lamb Joseph J,
Chang JyhLurn,
Hsi Alex,
Bland Jeffrey S,
Tripp Matthew L
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.739.1
Subject(s) - medicine , metabolic syndrome , apolipoprotein b , triglyceride , cholesterol , glycemic , endocrinology , phytosterol , food science , diabetes mellitus , insulin , chemistry
As cardiovascular disease risk is increased 4–6 fold in subjects when metabolic syndrome (MetS) and elevated LDL occur concomitantly, we evaluated effects of supplementing a therapeutic lifestyle program with a medical food and specific combination of phytonutrients in subjects with both conditions. We analyzed data from subjects with LDL ≥ 160 mg/dL enrolled in a 12‐week, 2‐arm randomized study of 42 adults with MetS, LDL ≥130 mg/dL, triglyceride (TG) ≥150<400 mg/dL and BMI ≥27 kg/m 2 . Both control (C) and treatment (T) arms consumed a Mediterranean‐style, low‐glycemic‐load diet and engaged in aerobic exercise. T received a medical food containing soy protein and plant sterols and a supplement containing rho iso‐alpha acids and acacia proanthocyanidins. 24 subjects, 12 in each arm, met subanalysis criterion of LDL≥160 mg/dL. At 12 weeks, weight loss did not differ between arms. However, T exhibited greater improvement than C (P<0.05) in total cholesterol, LDL, non‐HDL cholesterol, cholesterol/HDL, TG/HDL, apolipoprotein (apo) B, apoB/apoA‐1, and homocysteine, total LDL and large HDL particle number. All subjects in T but only 1/3 in C achieved LDL <160 mg/dL and 5 in T and 0 in C had LDL lowered to <130 mg/dL. High risk subjects with MetS and LDL ≥160 mg/dL may benefit from a soy/phytosterol containing medical food and phytonutrient supplemented therapeutic lifestyle program. Supported by MetaProteomics, LLC.