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Effects of nano‐silver administration for 4‐weeks on bone mineral density in growing rats
Author(s) -
Kang MyungHwa,
Yu Il Je,
Kim MiHyun,
Choi MiKyoung
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.738.9
Subject(s) - bone mineral , medicine , femur , silver nano , dual energy , significant difference , endocrinology , zoology , surgery , osteoporosis , nano , biology , physics , quantum mechanics
The present study was investigated the effect of nano‐silver administration on BMD in growing rats. Total 90 (male 45, female 45) rats in 5‐week age were used in this study. The animals were divided into three dose groups; vehicle control, low dose 100 mg/kg nano‐silver (average particle size=25 nm), and high dose 500 mg/kg nano‐silver group. Each group was composed of 30 rats (male 15, female 15). Nano‐silver was administered orally for 4 weeks. One group of rats was sacrificed at the end of 4 week administration, and other groups were allowed to recover for 1, 2 and 4 months to evaluate elimination of nano‐silver from various tissues, and to assess long‐term effects. After sacrifice, femur was processed for the assessment of BMD, and BMD of femur was measured by dual‐energy absorptiometry (DXA). There was no significant difference of femur BMD among the three groups at 0 month, 1 month and 2 month after different doses nano‐silver administration for 4 weeks. Our findings suggest that 4‐week administration of nano‐silver during growing stage of animal has no significant effects on BMD in male and female rats.