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Beta‐hydroxy‐beta‐methylbutyrate (HMB) Decreases Body Fat in Middle Aged and Old Rats
Author(s) -
Wilson Jacob Malachi,
Lee Sangrok,
Henning Paul,
Ugrinowitsch Carlos,
Grant Samuel,
Park Youngmin,
Masad Ihssan,
Leonard Ken Paul,
Zourdos Michael,
Bakhshalian Neema,
Panton Lynn,
Kim Jeongsu
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.736.1
Subject(s) - medicine , endocrinology , anabolism , adipose tissue , muscle mass
Adipose and muscle mass increase in Fisher 344 (F344) rats through midlife and decline thereafter. HMB increases fat oxidation and activates anabolic pathways in myotubes. We determined the effect of HMB on adiposity and muscle wet weights in F344 rats. Twelve young (44 wks), 6 middle aged (60 wks), 10 old (86 wks), and 5 very old (102 wks) male F344 rats’ body compositions were assessed using dual X‐ray absorptiometry (DXA) pre/post‐treatment. After DXA, 6 young, 6 middle aged, 5 old and very old rats were sacrificed for pre and post control muscle wet weights. Remaining young and old rats were given HMB (0.46 g/kg/d) for 16 wks. There was a group effect for body mass (BM) increasing (+23%) in the control, but not in the HMB group from 44–60 wks, while it maintained in the control, and declined (−20%) in the HMB group from 86–102 wks. There were declines in gastrocnemius, plantaris, and soleus weights normalized to BM from 60–102 wks. While HMB had no effects on the gastrocnemius, there were decreases in control planaris (−21%) and soleus (−15%) muscles, which maintained and increased (+12%), respectively, in the HMB group from 44–60 wks. Fat mass (g) increased in the middle aged control (+49%) but not in the HMB group. Fat mass declined (−56%) in the old HMB but not in the control. Our findings suggest HMB may produce a leaner phenotype in middle aged and older individuals. Future research is needed to elucidate the underlying mechanisms. Grant Funding Source : College of Human Sciences Internal Grant