Premium
Effect of dietary restriction and n‐3PUFA supplementation on insulin resistance in obese adults
Author(s) -
Tapsell Linda Clare,
Batterham Marijka Jane,
Charlton Karen Elizabeth
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.733.9
Subject(s) - overweight , insulin resistance , placebo , polyunsaturated fatty acid , medicine , obesity , analysis of variance , insulin , fish oil , endocrinology , fish <actinopterygii> , fatty acid , biology , biochemistry , alternative medicine , pathology , fishery
The type and amount of dietary fat, and in particular n‐3 PUFA, may influence insulin action. The aim of this study was to examine the effects on HOMA indices from increased n‐3 PUFA intakes at 3 and 6 months in a registered 12 month weight loss trial [ACTRN12608000425392]. The blinded RCT with 30 males and 88 females (aged 45+9.95yr; BMI 31.34+3.49kgm −2 ) compared a control diet (2MJ deficit, 30%fat + placebo) with two intervention groups (2MJ deficit, 30% fat emphasizing fish with placebo or supplement of 420mg EPA+ 210mg DHA). Differences between groups were assessed using repeated measures analysis of variance, where data was available at 0,3,6mo (n=73). A significant time effect was found for decreased HOMA‐R (inverse of %S) (P=0.001), with post hoc analysis showing a significant difference between 0–3mo (P=0.006) and 0–6mo (P=0.002). Values for the control group were higher than for the intervention groups but the effect was not significant at 3–6mo (P=1.000). No effect was seen for HOMA(%β) (N=72). Energy restriction appears to decrease insulin resistance in overweight adults in the first 3 mo, and there may be added benefits with food or supplemental n‐3 PUFA dietary enrichment. Source of research support: Australian National Health and Medical Research Council Project Grant #514631 Tapsell, Batterham, Charlton.