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Trunk fat and insulin resistance are positively correlated with carbohydrate intake and glycemic index in subjects classified with the metabolic syndrome
Author(s) -
LaPia Branden James,
Jones Jennifer,
Barona Jacqueline,
Calle Mariana,
Kim Jung Eun,
McIntosh Mark,
Kalynych Colleen,
Vukich Claire,
Najm Wadie I,
Volek Jeff S,
Fernandez Maria Luz
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.733.8
Subject(s) - medicine , adiponectin , insulin resistance , endocrinology , glycemic index , waist , metabolic syndrome , glycemic load , insulin , glycemic , carbohydrate , chemistry , body mass index , obesity
We evaluated markers of inflammation, adiponectin, body composition and diet in 88 women (25–72 y) classified with metabolic syndrome (MetS). Values for waist circumference (108.2 ± 11.2 cm) and plasma triglycerides (200.4 ± 53.3 mg/dL) were elevated. While plasma glucose levels varied from 66–179 mg/dL, 42% of women had insulin resistance. Plasma levels of Interleukin‐6 (IL‐6) (0.99–15.7 mg/L), tumor necrosis factor alpha (1.47–12.3 mg/L) and high sensitivity C‐reactive protein (0.06–3.08 mg/dL) varied widely with most women being above values considered normal.. Subjects reported energy consumption from 488 to 6276 kcal/d with the expected under‐reporting in obese subjects. Subjects had a high intake of both trans fatty acids (4.9 g/d) and sugar (92.3 ± 56.4 g/d) while dietary fiber (17.0 ± 9.0 g/d) was below the recommendations. Glycemic load was also high (127.2 ± 56.1). Plasma insulin was highly correlated with trunk fat (r = 0.848, P < 0.00001) while trunk fat was positively correlated with energy intake (r = 0.637, P < 0.0001), total CHO (r = 0.643, P < 0.0001) and total sugar (r = 0.573, P < 0.0001). Although adiponectin values were normal, 16.4 ± 8.2 mg/L, adiponectin was negatively correlated with added sugar (r = −0.318, P < 0.01) and glycemic index (r = −0.342, P < 0.05). These results suggest that high carbohydrate, high glycemic foods are strongly correlated with trunk fat and insulin resistance in subjects with MetS. [Supported by MetaProteomics, LLC, Gig Harbor, WA]