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Effect of a Short‐term Diet and Exercise Intervention in Children on Serum Lipomics and Markers of Metabolic Health
Author(s) -
Izadpanah Ali,
Barnard R. James,
Burant Charles F.,
Roberts Christian K.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.732.10
Subject(s) - overweight , medicine , endocrinology , resistin , metabolic syndrome , obesity , leptin , adipokine
The present study was designed to examine the effects of a short‐term diet/exercise program on markers of metabolic health and serum lipomics. 33 overweight children (15 boys, 18 girls, age 12.3±0.4 yr), were placed on an ad libitum, high‐fiber, low‐fat diet and daily exercise (2–2.5 hr) regimen in the Pritikin Longevity Center 2‐wk program. Fasting serum was taken pre‐ and post‐intervention for determination of glucose, lipids, metabolic risk markers, and lipomic analysis by gas chromatography. After 2 wks subjects lost weight (73.0±6.2 post vs. 75.7±6.5 kg pre) but remained overweight/obese (BMI: 27.2±1.7 vs. 28.2±1.8 kg/m 2 ). Despite remaining overweight, no subjects had metabolic syndrome post‐ compared with 8 pre‐intervention. RHR and BP decreased significantly, p<0.005. Serum TG, Total‐C, LDL (p<0.0001), PAI‐1, resistin, leptin (p<0.001), HDL, IL‐8, amylin and insulin (p<0.05) decreased significantly. Serum IL‐10 (p=0.14) and IL‐1ra (p=0.29) increased and VEGF (p=0.07) decreased non‐significantly. Lipomic analysis revealed decreases in total lipids (79% of baseline), saturated fatty acids (14:0, 82%, 18:0, 87% and 20:0, 33%), and increases in 20:1 (125%), 22:6 (144%) and 18:1/18:0 (114%), all p<0.05. These results indicate changes in multiple indices of metabolic health and serum lipomics with short‐term, rigorous lifestyle modification, even in the face of remaining overweight/obese. This study was supported by a grant from the L‐B Research/Education Foundation and funding from UCLA.