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Baseline plasma PTH but not calcium supplementation influence reduction in adiposity of obese children followed during 6 months
Author(s) -
Donangelo Carmen Marino,
Taam Walter,
Bezerra Flávia Fioruci,
Mendonça Laura
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.731.2
Subject(s) - medicine , insulin resistance , endocrinology , body mass index , obesity , homeostatic model assessment
The aim of this study was to identify factors associated with changes in body mass index (BMI) and adiposity of obese children (n=35; age 8.0 ± 1.8 y; dietary Ca ≈ 550 mg/d) followed during 6 mo. All children and families received nutrition and life‐style counseling. Some children (n=14) used a Ca supplement (500 mg Ca/d, as glycinate chelate). BMI and adiposity (% fat: total, TF; android, AF; gynoid, GF) determined by DXA were measured before and after treatment. Plasma iPTH, insulin resistance (IR), total cholesterol (CH) and LDL were measured at baseline. Information on physical activity (PA) and family environment (FE) was obtained. Statistical analysis was done by a General Linear Model with categorical and quantitative factors. Models had 47–61% R 2 and P <0.03. PA and a cooperative FE were positive factors for reducing TF, AF and GF. LDL, IR, and CH were positive factors for reducing BMI, TF, and GF, respectively. Use of Ca supplement was a positive factor for reducing BMI but not adiposity. PTH was a negative factor for reducing BMI, and also TF, AF and GF. Our results suggest that adiposity in children is associated with the PTH‐vitD‐Ca homeostatic system. Financial support: CNPq, FAPERJ (Brazil)