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A synthetic fiber affects early calcium metabolism and inulin‐based fibers affect bone biomechanical properties in ovariectomized rats
Author(s) -
Legette LeeCole L,
Martin Berdine R,
Campbell Jessica K,
Weaver Connie M
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.726.4
Subject(s) - ovariectomized rat , polydextrose , calcium , medicine , endocrinology , osteoporosis , bone remodeling , chemistry , inulin , calcium metabolism , estrogen , food science
Age‐related deficiencies in calcium metabolism play a role in the development of osteoporosis. Recent evidence indicates that various dietary fibers may enhance calcium absorption and attenuate post‐menopausal bone loss. A 4‐ wk feeding study was conducted in 5 mo. old ovariectomized (OVX) Sprague Dawley rats to assess the effect of various dietary fibers on calcium metabolism and bone health parameters. There were 6 treatment groups (n=16/group): SHAM Control, OVX Control, OVX rats receiving daily estradiol injections, and OVX rats receiving an AIN 93M diet supplement with either an inulin based fiber (Synergy® or Frutafit®) or a synthetic fiber (Polydextrose) at 5%. Calcium metabolic balance was performed after early exposure (3 d) to dietary treatments. Rats receiving polydextrose had significantly higher net calcium absorption efficiency than all control groups and a trend (p≤0.10) for higher calcium absorption when compared to inulin‐based fibers. Rats consuming Synergy® and Frutafit®, as well as rats receiving daily E2 injections, had similar femoral breaking strength as SHAM control and higher than OVX Control and OVX rats on Polydextrose. Grant Funding Source : General Mills