A synthetic fiber affects early calcium metabolism and inulin‐based fibers affect bone biomechanical properties in ovariectomized rats

Age‐related deficiencies in calcium metabolism play a role in the development of osteoporosis. Recent evidence indicates that various dietary fibers may enhance calcium absorption and attenuate post‐menopausal bone loss. A 4‐ wk feeding study was conducted in 5 mo. old ovariectomized (OVX) Sprague Dawley rats to assess the effect of various dietary fibers on calcium metabolism and bone health parameters. There were 6 treatment groups (n=16/group): SHAM Control, OVX Control, OVX rats receiving daily estradiol injections, and OVX rats receiving an AIN 93M diet supplement with either an inulin based fiber (Synergy® or Frutafit®) or a synthetic fiber (Polydextrose) at 5%. Calcium metabolic balance was performed after early exposure (3 d) to dietary treatments. Rats receiving polydextrose had significantly higher net calcium absorption efficiency than all control groups and a trend (p≤0.10) for higher calcium absorption when compared to inulin‐based fibers. Rats consuming Synergy® and Frutafit®, as well as rats receiving daily E2 injections, had similar femoral breaking strength as SHAM control and higher than OVX Control and OVX rats on Polydextrose. Grant Funding Source : General Mills