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Curcuma or citrus extract supplementation does not improve body condition nor insulin sensitivity in obese cats
Author(s) -
Leray Veronique,
Jeusette Isabelle,
Serisier Samuel,
Freuchet Benjamin,
Torre Celina,
Nguyen Patrick
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.725.2
Subject(s) - endocrinology , leptin , medicine , basal (medicine) , insulin , cats , obesity , curcuma , adiponectin , insulin resistance , traditional medicine
The putative therapeutic properties of curcuma and citrus could be associated with their antioxidant and anti‐inflammatory properties. Our aim was therefore to examine the effects of citrus or curcuma extract supplementation on body condition and inflammatory state in obese cats. Eight obese cats participated in this study that was conducted as a cross‐over, with two 8‐week periods. The diets were supplemented with either curcuma or citrus extract. Body composition (D 2 O dilution method), insulin sensitivity (euglycemic hyperinsulinemic clamp technique), plasma leptin level (RIA), and TNFα, IL1β and IFNγ mRNA expression in leucocytes (real‐time PCR) was assessed prior to and at the end of the test period. Body weight was unchanged by either diet. Both diets lowered fat‐free mass whereas the percentage of fat mass increased. Basal glycemia, basal insulinemia, insulin sensitivity and plasma leptin level were not modified whatever the diet. TNFα, IL1β and IFNγ mRNA levels were not affected by either diet. Similar plasma leptin level in both groups is consistent with their body weight and body composition. Our results suggest that curcuma or citrus extract supplementation is not effective in improving body weight, body composition, insulin sensitivity, or inflammatory state in obese cats.