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The effects of a variable dose vegetable feeding on plasma carotenoids in overweight post menopausal women
Author(s) -
Crane Tracy E,
West Julie,
Kroggel Mark,
Hartz Vern,
Kubota Chieri,
Thomson Cynthia
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.724.17
Subject(s) - carotenoid , overweight , medicine , oxidative stress , food science , zoology , lycopene , obesity , chemistry , biology
Significant debate exists regarding the optimal amount of vegetable consumption required to reduce chronic disease risk. Intervention trials evaluating biological activity of vegetables at various doses are limited. A 3‐dose, cross‐over feeding trial is underway to test the hypothesis that vegetable intake is associated in a dose‐dependent manner with increased plasma carotenoids and subsequently reduced oxidative stress and inflammation in overweight post‐menopausal women. Subjects were assigned in random order to 2,5 or 10 servings of fresh, greenhouse‐grown vegetables daily for 3‐week intervals with 4‐week washouts between feedings. All 48 enrolled subjects (mean age 58.8, BMI 33.08) completed the trial. A significant dose‐response for plasma carotenoids has been observed with mean plasma total carotenoids increasing from 91.14 mg/dL to 115.56 mg/dL with 2 servings vegetables, from 83.97 mg/dL to 156.14 mg/dL with 5 servings of vegetables and from 77.85 mg/dL to 240.90 mg/dL with 10 servings of vegetables (difference btw 2 and 5 svgs, p=0.000; difference btw 5 and 10 svgs, p=0.000). Whether these significant increases in carotenoids by dose are associated with subsequent improvements in oxidative stress and inflammation biomarkers remains to be evaluated.