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EFFECT OF RESVERATROL ON IMMUNE STATUS IN MICE
Author(s) -
Jung Jihye,
Park Sujin,
Jin Heemin,
Lee Bora,
Kim HyunSook
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.723.18
Subject(s) - resveratrol , immune system , splenocyte , cytokine , chemistry , immunity , pharmacology , immunology , medicine
Resveratrol, a naturally occurring polyphenol, shows health beneficial effects. The aim of this study was to investigate the effect of resveratrol on the immune status and anti‐oxidant activity in mice. In the in vivo study, mice were randomly assigned to a control diet or a resveratrol diet. Resveratrol (25 mg/kg b.w. or 500 mg/kg b.w.) was orally administered every day throughout the experiment period. The splenocyte proliferation, leukocyte percentage, cytokine production, percent of CD4+ & CD8+ were measured after 14 days and percent of H2O2, nitrite oxide (NO) were evaluated every 3 other days. The levels of body weight were significantly increased in 25 mg/kg b.w. of resveratrol administration group. The percent of monocyte, eosinophil, basophil were also significantly increased in same concentration resveratrol group. On the other hand, there was no significance among the other parameters; cytokine production, percent of CD4+ & CD8+, and anti‐oxidant activity. In this study, we try to examine the anti‐oxidant activity and immunity of resveratrol on healthy mice. Considering the whole experimental period was limited to 14 days, the period may not be long enough to see the significant change in other immune index.