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Quercetin from Onion Peel Extract Improves the Features of Metabolic Syndrome in Male Smokers
Author(s) -
Lee Kyunghea,
Lee Hye jin,
Kim Myeong ok,
Cha Young jun,
Park Eunju,
Shin Min jeoung
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.722.24
Subject(s) - quercetin , placebo , blood pressure , metabolic syndrome , medicine , cholesterol , lipid profile , blood lipids , endocrinology , obesity , chemistry , biochemistry , antioxidant , alternative medicine , pathology
Objective This study tested the effects of supplemental quercetin derived from onion peel extract on the components of metabolic syndrome in healthy male smokers. Methods Randomized assigned subjects were instructed to take either a placebo (n=43) or 4 quercetin capsules per day for a total of 100 mg of quercetin (n=49). Blood pressure and blood lipids were measured at baseline and after 10 weeks of intervention. Results Quercetin supplementation significantly reduced serum total cholesterol (p<0.05) and LDL‐cholesterol (p<0.01), whereas these effects were not shown in the placebo group. In addition, there were significant increases in serum HDL‐cholesterol both in the placebo (p<0.005) and quercetin supplementated group (p<0.001); however, changes in HDL‐cholesterol were significantly greater in subjects receiving supplemental quercetin compared to the placebo. Both systolic (p<0.05) and diastolic blood pressure (p<0.01) was significantly reduced in the quercetin supplemented group. Glucose levels were significantly decreased after 10 weeks of quercetin supplementation (p<0.05). Conclusions The results will be discussed that daily supplementation of onion peel extract improved the components of metabolic syndrome including blood lipid profiles, glucose and blood pressure, suggesting quercetin's beneficial role in onion peel extracts as a preventive measure against cardiovascular risks.