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Hypolipidemic effect of onion skin in ob/ob mice
Author(s) -
Kang Minjung,
Kim Jungin,
Choi Haneul,
Kang Younghee
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.722.23
Subject(s) - triglyceride , hyperlipidemia , chemistry , medicine , endocrinology , cholesterol , obesity , blood lipids , biology , biochemistry , diabetes mellitus
Obesity is often accompanied by hyperlipidemia. Onion skin has pancreatic lipase inhibitory activity and may regulate hepatic lipid accumulation. The purpose of this study is to evaluate effect of onion skin on body weight, blood lipid profile and hepatic lipid accumulation in ob/ob mouse. Six week‐old ob/ob mice (C57BL/6J, n=14) were fed AIN‐93G diet or diet containing 1% fermented alcohol extract of onion skin for 8 weeks. Body weight and food intake of onion skin group were not significantly different from those of the control group. Extraction of lipids from liver was performed using the method of Folch et al. Serum glucose, triglyceride and total cholesterol levels and hepatic triglyceride levels were measured by enzymatic methods. Serum glucose, triglyceride and total cholesterol levels of onion skin group were significantly lower than the control group (P<0.05). Consumption of onion skin extract significantly reduced total lipid content and triglyceride level of liver compared with the control group. Thus we concluded that onion skin could be beneficial on hyperlipidemia and hepatic lipid accumulation in ob/ob mouse. This study was supported by the National Research Foundation of Korea (NRF).