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Hypoglycemic effect of quercetin in animal models of diabetes
Author(s) -
Choi Haneul,
Kim Jungin,
Kim Jihye,
Joo Heejeong,
Kang Younghee
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.722.22
Subject(s) - postprandial , quercetin , glycated hemoglobin , diabetes mellitus , medicine , streptozotocin , ingestion , endocrinology , type 2 diabetes , chemistry , biochemistry , antioxidant
Tight control of fasting and postprandial hyperglycemia is crucial for the management of diabetes mellitus. Quercetin was reported to have strong alpha‐glucosidase inhibitory activity in vitro. The purpose of this study was to investigate the hypoglycemic effect of quercetin in animal models of diabetes. The effect of the quercetin on the postprandial hyperglycemia was studied in streptozotocin‐induced diabetic rats (n=12) using a carbohydrate load test. Oral administration of quercetin (100 mg/kg) significantly decreased incremental serum glucose levels at 60 and 90 min (P < 0.05) after an oral ingestion of starch (1 g/kg). The area under the glucose response curve of the quercetin group was significantly reduced compared with that of the control group (p<0.01). The effect of chronic feeding of quercetin was studied in an animal model of type 2 diabetes. Four‐week‐old db/db mice (n=14) were fed AIN‐93G diet with and without quercetin (100 mg/kg) for 7 weeks. Consumption of quercetin significantly decreased serum glucose and blood glycated hemoglobin levels compared with the control group (P < 0.05). These results indicate that quercetin is effective in controlling hyperglycemia in animal models of diabetes mellitus. This study was supported by the National Research Foundation of Korea (NRF).