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Effects of Opuntia ficus indica on Glucacon like peptide (GLP‐1), Glucose‐dependent insulinotropic peptide (GIP), blood glucose and insulin after the consumption of a high carbohydrate meal
Author(s) -
LopezRomero Patricia,
MoranRamos Sofia,
Tovar Armando R,
Torres Nimbe
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.722.2
Subject(s) - cladodes , meal , insulin , postprandial , medicine , endocrinology , carbohydrate , chemistry , food science , biology , botany , cactus
Opuntia ficus‐indica (nopal), a plant widely consumed in Mexico has shown to be rich in bioactive compounds such as dietary fiber, polyphenols and calcium with antihyperglycemic properties in diabetic subjects; however, the mechanism of action has not been elucidated. The physicochemical characteristics of Opuntia cladodes (OC) are mainly responsible for these effects, however these can be modified by OC processing. The aim of this work was to evaluate whether the consumption of different preparations of OC with a high carbohydrate meal (HCM) modify the blood glucose, insulin, GIP and GLP‐1 response. Eight healthy volunteers were given a HCM in the presence of five different cladode preparations after a 12 h fast. Blood samples were drawn before and 15, 30, 45, 60, 90, 120 min following the HCM. The results showed that consumption of OC with the HCM modulates the area under the curve (AUC) for GIP and GLP‐1 and that this is influenced by the cladode preparation. The AUC for insulin, shows a reducing tendency (P = 0.06) during the two hour period. The latter reduction is lost when OC are given dehydrated in aqueous solution. There was no significant difference in glucose AUC in the normoglycemic subjects. These results suggest that one possible mechanism for the physiological effect of Opuntia may be partly mediated by incretins and depended of the OC processing. Supported by ICyT DF (PICDS08‐6) and Grupo Produce