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Effect of helicobacter pylori infection on iron absorption in asymptomatic adults consuming iron and zinc fortified wheat
Author(s) -
Romaña Daniel Lopez,
Diazgranados Doricela,
Pizarro Fernando,
Ruz Manuel,
Brunser Oscar
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.717.11
Subject(s) - ferrous , micronutrient , zinc , asymptomatic , ferrous sulphate , iron deficiency , absorption (acoustics) , chemistry , sulfate , food science , helicobacter pylori , medicine , gastroenterology , inorganic chemistry , anemia , materials science , organic chemistry , composite material
Micronutrient deficiencies and Helicobacter pylori (HP) infection are prevalent and co‐exist in several countries. Objective The objective of the study was to determine the effect of HP on iron absorption in asymptomatic adults consuming iron and zinc fortified wheat. Materials/Methods HP was assessed using the C13‐urea breath test. On day 1 subjects received for breakfast bread fortified, per Kg flour, with either 55 mg ferrous sulfate and 60 mg zinc sulfate, labeled with 59Fe, as sulfate, or same amounts of ferrous fumarate and zinc oxide, labeled with 55Fe, as fumarate. On day 3 they received the other type of bread. On day 17 blood (20 ml) was drawn to assess circulating radioactivity. Iron absorption was determined using Eakins and Brown's double isotopic technique. Results/Findings Prevalence of HP was 78%. Fourteen HP negative and 16 HP positive individuals completed absorption studies. There were no significant differences in the mean iron absorption of either ferrous sulfate or ferrous fumarate by infection status. Conclusion HP has no effect on iron absorption in asymptomatic adults consuming iron and zinc fortified wheat. Support by FONDECYT grant 1080032