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Ring finger protein 14 regulates beta‐catenin/TCF‐mediated transcription
Author(s) -
Wu Beibei,
Piloto Sarah,
Schilling Thomas F,
Waterman Marian L
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.713.7
Subject(s) - wnt signaling pathway , enhancer , transcription factor , tcf4 , beta catenin , microbiology and biotechnology , zebrafish , biology , activator (genetics) , transcription (linguistics) , lrp6 , lrp5 , sp3 transcription factor , e box , regulator , signal transduction , gene , genetics , philosophy , linguistics
Beta‐catenin‐dependent Wnt signaling controls many fundamental events during development and homeostasis. Beta‐catenin and transcription factors of the T cell factor/lymphoid enhancer factor (TCF/LEF) family interact with many protein factors and cooperatively regulate gene transcription. We have discovered ring finger protein 14 (RNF14) as a positive regulator of Wnt signaling in both mammalian cells and zebrafish. RNF14 interacts with TCF1 and can be recruited to response elements in Wnt target genes. We have also demonstrated that RNF14 is required for efficient activation of Wnt signaling and that it helps stabilize beta‐catenin recruitment to DNA. RNF14 has been reported as a co‐activator of androgen receptor (AR)‐mediated transcription; however we have found that RNF14 participates in the Wnt pathway independent of AR signaling. Thus our findings suggest a novel role of RNF14 in enhancing beta‐catenin/TCF‐mediated transcription.