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NAD+ Treatment Induces Tumor Cell Necrosis by P2X7 Receptor‐Independent Pathways
Author(s) -
Zhao Cuiping,
Hong Yunyi,
Han Jin,
Xia Weiliang,
Ying Weihai
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.703.16
Subject(s) - nad+ kinase , nicotinamide , apoptosis , programmed cell death , cancer cell , cancer , nicotinamide adenine dinucleotide , necrosis , cancer research , cell , receptor , poly adp ribose polymerase , chemistry , biology , microbiology and biotechnology , medicine , biochemistry , enzyme , polymerase
NAD+ plays important roles in various biological processes. The aim of this was to determine the effects of NAD+ on the survival of cancer cells. We found that NAD+ treatment can dose‐dependently and time‐dependently induce the necrosis of various types of cancer cells without producing apoptosis. Our study has also excluded the possibilities that NAD+ induces the cell death through its degradation product nicotinamide, and that P2X7 receptors mediate the effects of NAD+ on cancer cells. Our study has provided evidence indicating NAD+ as a novel cancer cell‐killing agent, and suggested presence of novel NAD+‐dependent mechanisms for inducing cancer cell death. (Supported by a Key Research Grant of Shanghai Municipal Education Committee, by Shanghai Engineering Center Grant of Equipment and Technology of Physical Therapy for Major Diseases, and by a 973 Grant 2010CB834306)