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Effect of administration of ethanol extract of Eryngium carlinae on diabetic rats
Author(s) -
NoriegaCisneros Ruth,
OrtizAvila Omar,
SalgadoGarciglia Rafael,
ArellanoPlaza Melchor,
ClementeGuerrero Mónica,
ManzoAvalos Salvador,
SaavedraMolina Alfredo
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.660.5
Subject(s) - polydipsia , diabetes mellitus , medicine , streptozotocin , oral administration , polyuria , ethanol , antioxidant , body weight , traditional medicine , pharmacology , endocrinology , chemistry , biochemistry
Diabetes mellitus is a metabolic disorder of multiple etiologies, characterized by chronic hyperglycemia, that is directly related to the development of long‐term complications which determine the quality of life of diabetic patients. At present is counted a variety of palliative medicine to treat this disease, however, some are beyond the reach of all people by their high cost. Objective The aim of this study was to investigate the effect of administration of the ethanol extract of Eryngium carlinae (EC) in diabetic rats. Methods Were measured glucose levels in blood and weight of the rats, likewise, was measured the food and water intake for 30 days, during which conducted oral administration (in drinking water) of the extract in a dose of 150 mg/kg. Diabetes was induced by a single injection (ip) of streptozotocin (40 mg/kg), rats with glucose levels above 300 mg/dL were used to shape the diabetic groups. Results The administration of extract of EC had no hypoglycemic effect; however, its use was able to reduce the weight loss characteristic of diabetic model. The symptoms of polyphagia and polydipsia were present in the diabetic group, as evidenced by the high consumption of food and water, compared with a no diabetic group (p <0.01) despite receiving treatment with extract. Conclusion Due to the results, currently being tested by varying the route of administration and dose of EC extract to find effective dose is also possible to evaluate the antioxidant activity of extract in different organs.