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Roles of HDV‐like self‐cleaving ribozymes in retrotransposition
Author(s) -
Ruminski Dana,
Webb ChiuHo Ts,
Riccitelli Nathan J,
Luptak Andrej
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.653.4
Subject(s) - retrotransposon , ribozyme , biology , reverse transcriptase , gene , integrase , genetics , genome , rna , virology , computational biology , transposable element
Using structure‐based bioinformatics, we recently discovered self‐cleaving ribozymes of the Hepatitis Delta Virus (HDV) family in another virus, a bacterium, and many eukaryotes. The genomic locations of some of these ribozymes suggest that they play a variety of biological roles. HDV‐like ribozymes from several organisms are associated with putative reverse transcriptase genes and retrotransposons, pointing to a possible function in retrotransposition. The specific roles of HDV‐like ribozymes in retrotransposition are being investigated using a variety of in vitro and in vivo approaches.