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Sural nerve morphology in hypertensive rats with chronic diabetes
Author(s) -
Sanada Luciana Sayuri,
Tavares Marcelo Rodrigo,
Neubern Milena,
Fazan Valéria Paula
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.643.5
Subject(s) - sural nerve , medicine , diabetes mellitus , streptozotocin , diabetic neuropathy , peripheral neuropathy , exacerbation , peripheral , endocrinology , anatomy
Despite that the association between hypertension and diabetes is common in clinical practice, the contribution of each isolated entity in the neuropathy development is still not known. The literature lacks a morphologic description of peripheral nerves in experimental models of hypertensive diabetic animals. The present study compared the sural nerve in Wistar rats (WR), WR with chronically induced diabetes, spontaneously hypertensive rats (SHR) and SHR with chronically induced diabetes, using a morphological approach. Female SHR and WR, 8 weeks old, received a single intravenous injection of streptozotocin (STZ) through the caudal vein. Twelve weeks after the injection, right and left sural nerves were dissected and proximal and distal segments were prepared for light microscopy. Morphometry was performed with the aid of computer software. Fascicular and myelinated fiber data from sural nerves in control and diabetic WR are statistically larger compared to SHR and diabetic SHR. Hypertension did alter the morphology and morphometry of the fascicles and myelinated fibers of the sural nerves in control SHR compared to control WR. Chronic diabetes also induced alterations of the morphology and morphometry of sural nerve. Hypertension alteration caused an exacerbation of the diabetic alterations already observed in neuropathic degeneration of sural nerves. Grant Funding Source : FAPESP