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ALP to PTH Ratio in Young and Old Females
Author(s) -
Wilson Zechariah,
Lau Cecilia,
Caporaso Fred,
Sumida Ken,
Frisch Frank
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.630.9
Subject(s) - alkaline phosphatase , parathyroid hormone , medicine , endocrinology , osteoporosis , bone health , age groups , chemistry , bone mineral , calcium , enzyme , biochemistry , demography , sociology
For the purpose of establishing a clearer age‐related profile of bone health our aim was to evaluate the ratio of osteoblastic marker bone‐specific alkaline phosphatase (ALP) to circulating parathyroid hormone (PTH) concentrations in 119 healthy women in two age groups (16–46, and 47–70 years of age) who were not on bisphosphonates or other osteoporosis therapies. The ALP increases from 8.5 mcg/l in younger women to 11.3 mcg/l (p<.0008). The PTH values also significantly increased (28.1 to 37.4 pg/ml, respectively; p<.020). The ALP:PTH ratio is unchanged (.30) for the two age groups. Our data holds promise for identifying an age‐related profile that can be used to illuminate the metabolic status of bone.