Premium
Effect of pyridostigmine on the sympathovagal balance and cardiac morphometry in heart failure
Author(s) -
Lataro Renata M,
Silva Carlos Alberto A,
Prado Cibele M,
Rossi Marcos A,
Fazan Rubens,
Salgado Helio C
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.625.10
Subject(s) - pyridostigmine , heart failure , medicine , ventricle , cardiology , propranolol , heart rate , endocrinology , anesthesia , blood pressure , myasthenia gravis
Sympathovagal balance and cardiac morphometry were evaluated in heart failure (HF) rats, 4 weeks after treatment with the reversible acetylcholinesterase inhibitor pyridostigmine (PYR). HF was produced by left coronary artery ligation under anesthesia. Conscious animals were equipped with catheters in the femoral artery and vein. Methyl atropine and propranolol were used to evaluate the sympathovagal balance and the intrinsic heart rate (IHR). In HF rats PYR reduced heart rate (Control: 335±5; HF: 388±11; HF+PYR: 347±4 bpm), increased vagal tone (Control: 92±13; HF: 40±8; HF+PYR: 107±9 bpm), reduced sympathetic tone (Control: 19±4; HF: 47±9; HF+PYR: 23±5 bpm) and did not change IHR (Control: 377±5; HF: 392±6; HF+PYR: 394±8 bpm) or cardiac/body weight ratio (Control: 2.9±0.1; HF: 3.5±0.1; HF+PYR: 3.6±0.1 mg/g). However, PYR reduced the diameter of the myocytes from the left ventricle (Control: 13.2±0.2; HF: 19.9±0.6; HF+PYR: 17.0±0.5 ìm). In conclusion, it was demonstrated that pyridostigmine increased cardiac vagal tone and reduced the sympathetic tone without changing the IHR of HF rats. In addition, PYR reduced the diameter of the myocytes from the left ventricle. Support: FAPESP, CNPq and CAPES.