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Cardiovascular responses to ATP into the nucleus of the solitary tract in AV3V‐lesioned rats
Author(s) -
DE PAULA PATRICIA M.,
ZANELLA DAIANA C.,
TAKAKURA ANA C.,
COLOMBARI EDUARDO,
MENANI JOSE V.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.624.14
Subject(s) - medicine , endocrinology , glutamate receptor , solitary tract , heart rate , bradycardia , blood pressure , chemistry , central nervous system , receptor
Adenosine‐5□Œ‐triphosphate (ATP) and glutamate injected into the nucleus of the solitary tract (NTS) in awake rats increase mean arterial pressure (MAP) and reduce heart rate (HR). Electrolytic lesions of the anteroventral third ventricle (AV3V) reduce pressor response produced by glutamate into the NTS and studies have shown connections between the AV3V and NTS. Thus, in the present study, we investigated the effects of acute (1 day) electrolytic lesions of the AV3V region on the pressor and bradycardic responses induced by ATP into the NTS in unanesthetized rats. Male Holtzman rats with sham or electrolytic (2 mA × 10 s) AV3V lesions and a stainless steel cannula implanted into the NTS were used. The pressor response produced by injections of ATP (2.5 nmol/100 nl) into the NTS was reduced in 1 day AV3V‐lesioned rats (28 □} 3 mmHg, vs. sham lesions: 42 □} 3 mmHg, p<0.05). In the same AV3V‐lesioned rats, glutamate (5 nmol/100 nl) injected into the NTS reduced MAP (−29 □} 3 mmHg), while in sham rats glutamate induced pressor responses (51 □} 7 mmHg). The bradycardia to ATP into the NTS were reduced in AV3V lesioned rats (−65 □} 14 bpm, vs. sham lesions: −153 □} 14 bpm, p<0.05). The results show that AV3V lesions reduce the cardiovascular responses to ATP into the NTS, similar to previously demonstrated for glutamate into the NTS, reinforcing the importance of the AV3V region for the cardiovascular responses produced by the activation of NTS.