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An initial transient is followed by steady‐state regulation of blood pressure during hibernation bouts in the Syrian hamster
Author(s) -
Song Christine E,
Pham Hai,
Hamilton Jock S,
Horowitz John M,
Horwitz Barbara A,
Chen ChaoYin
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.623.6
Subject(s) - hibernation (computing) , hamster , blood pressure , mesocricetus , heart rate , medicine , biology , mean arterial pressure , endocrinology , chemistry , state (computer science) , algorithm , computer science
Hamster blood pressure and heart rate decrease during hibernation to conserve energy, but it is unclear how blood pressure changes over the course of a hibernation bout. We tested the hypothesis that blood pressure falls and then slightly recovers to a stable, regulated state during a hibernation bout. A blood pressure telemetry transmitter was implanted in a Syrian hamster (Mesocricetus auratus) for continuous recordings. Each hamster was placed in a 14:10 Light:Dark cycle at 23°C for 3 weeks and then transferred to a 8:16 Light:Dark cycle at 6°C. While euthermic, the hamster maintained mean arterial pressure at 87 ± 3 mmHg and heart rate at 352 ± 16 bpm at ambient temperatures of 23°C as well as at 6°C. Each hamster displayed multiple 3–5 day hibernation bouts. Each bout showed a two stage pattern: an initial, labile period (< 1 day) where mean pressure transiently decreased (for some bouts as low as 20 mmHg) and a steady period (2–4 days) where mean pressure was maintained at 46 ± 4 mmHg. Spontaneous baroreflex sensitivity, normalized to baseline heart rate, was −2.7 ± 1.5 and −6.7 ± 2.5 (during euthermia and hibernation, respectively). Data support the hypothesis that following a transient, mean arterial pressure is stable during a bout of hibernation. (Support: R01 HL091763)