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Impact of dietary fish oil on the atrial endothelin system and inositol triphosphate signaling: relevance to post‐operative atrial fibrillation
Author(s) -
Mayyas Fadia,
Sakurai Seiichiro,
Niebauer Mark,
Chung Mina K,
Van Wagoner David R
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.622.6
Subject(s) - atrial fibrillation , medicine , fish oil , endothelin receptor , endothelin 1 , inositol , endocrinology , cardiology , receptor , biology , fish <actinopterygii> , fishery
Background Endothelin‐1 (ET‐1) modulates inositol triphosphate (IP3) signaling and may be involved in the etiology of atrial fibrillation (AF). We hypothesized that ET‐1 is also involved in post‐operative AF (POAF), and that ET‐1 signaling may be modulated by fish oil, FO. In a cardiac surgery model we studied the impact of dietary fish oil (FO) on inducibility of POAF and atrial ET system/IP3 receptors. Methods Adult dogs received control chow (n=10), or chow supplemented with FO (EPA/DHA, 0.6g/Kg/day, n=9) for 3 weeks. Surgery was performed to excise left atrial appendage (LAA, internal CTL). Atrial burst pacing (30s) was used daily to assess AF inducibility. Left and right atria (LA, RA) and pulmonary veins (PV) were obtained on terminal postoperative day (POD) 2 or 4. Results POAF was induced in 4/6 CTL but none of FO treated dogs. Plasma ET‐1 did not change after surgery, but was reduced by FO prior to surgery and at POD 1–4. Relative to baseline LAA, LA ET‐1 level was increased after surgery in both groups. ET‐1 content in the PV and RA was 2× higher than LA and was lowered by FO on the PV and LAA. After surgery, ETBR and ETAR expression was decreased in CTL LA, while IP3R‐I,II was increased. In FO group, ETAR expression was unchanged (POD2) or increased (POD4), but IP3R‐II was unchanged. Conclusions Our study links the atrial ET system and IP3Rs with POAF. Peri‐operative FO may in part suppress POAF by modulating IP3 signaling.