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The influence of the intensity of a single bout of aerobic exercise on endothelial function in obese post‐menopausal women
Author(s) -
Cheek Dennis Jefferson,
Boyd Kara,
Mitchell Joel
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.619.7
Subject(s) - medicine , brachial artery , endothelial dysfunction , aerobic exercise , cardiology , analysis of variance , treadmill , repeated measures design , endocrinology , blood pressure , physical therapy , statistics , mathematics
Endothelial dysfunction increases the risk of cardiovascular disease, and regular exercise has been shown to increase endothelial function (EF); however, single bouts of exercise may also produce beneficial effects lasting at least 24 h. Purpose The purpose of this study was to observe the effects of two intensities of a single bout of aerobic exercise on endothelial function (EF) in obese, post‐menopausal women. Methods Eleven obese (% fat = 37.23 ± 2.75; BMI = 30.57 ± 2.14) women between the ages of 54 and 70 yrs completed two, one‐hour sessions of treadmill exercise at 50 and 70% of HR max , and a resting control trial. EF was assessed via flow‐mediated dilation (FMD) of the brachial artery and via blood levels of nitrate/nitrite (N/N) before and after exercise and at two, 24, 48, and 72 hours post exercise. FMD was measured by ultrasound images of the brachial artery before and for 5 min after 5 min of occlusion. A 3 × 6 repeated measures ANOVA was used to examine differences between condition and time for FMD and blood measures. Results Data at 24 h post exercise are shown below (mean ± SD).Condition FMD Max (mm) Δ Dilation (%) AUC N/N (μM)Control 3.75±0.58 0.14±4.87 8.09±5.68 9.09±4.13 50 % HR max 3.82±0.62 5.64±9.18 10.28±5.89 7.01±2.99 70% HR max 3.91±0.70 4.28±10.40 8.86±5.89 7.57±4.75None of the responses were significantly different from each other; however, there was a tendency for a greater Δ dilation in the 50% condition (p=0.075). Conclusion In elderly, obese females, one hour of exercise did not impact subsequent FMD responses, nor the blood markers of EF at any time points, regardless of the exercise intensity.