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Sex‐specific effects of atorvastatin on the blood pressure response to exercise
Author(s) -
Dostaler Edward G,
Thompson Paul D,
Axtell Robert S,
Latchman Peter,
Parker Beth A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.619.6
Subject(s) - blood pressure , atorvastatin , medicine , pressor response , placebo , analysis of variance , cardiology , repeated measures design , vo2 max , physical therapy , heart rate , mathematics , statistics , alternative medicine , pathology
Purpose To examine the effect of statin therapy on the blood pressure response to exercise in healthy adults. Methods Sixty eight adults (n=34 men (M) and women (W); ages 23–67) were randomized to atorvastatin 80 mg (A) daily or placebo (P) in a double blind fashion. Systolic, diastolic and mean arterial blood pressure (SBP, DBP and MAP, respectively) were measured every 3 minutes during a graded maximal exercise test with concurrent assessment of oxygen uptake (VO 2 ) pre‐ and post‐6 months of treatment. The slope of the blood pressure response to exercise was calculated as Δ SBP, DBP or MAP/Δ VO 2 (as % of VO 2max ). A repeated‐measures ANOVA with between‐subject factors of gender and drug was used to investigate slopes across time. Results The time*drug* gender interaction was marginally significant (both p = 0.06) for both the SBP and MAP response to exercise. Specifically, A reduced the slope of the pressor response to exercise in W but not M relative to P groups. Summary These findings suggest that atorvastatin may reduce the pressor response to exercise in women but not men. Supported by 1R01HL081893‐03.