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Effect of short‐term training on markers of inflammation in a swine model of atherosclerosis
Author(s) -
Masseau Isabelle,
Bowles Douglas K
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.619.13
Subject(s) - enos , ex vivo , medicine , inflammation , cardiology , vcam 1 , endothelium , brachial artery , common carotid artery , artery , endothelial dysfunction , cell adhesion molecule , endocrinology , carotid arteries , icam 1 , in vivo , nitric oxide synthase , blood pressure , nitric oxide , biology , immunology , microbiology and biotechnology
Endothelial dysfunction and inflammation (i.e. vascular cell adhesion molecule‐1 [VCAM‐1] expression), are early events in the development of atherosclerosis. Short‐term exercise training (Ex) enhanced endothelium‐dependent dilation (EDD) in coronary and brachial arteries. The objective of the study was to determine if Ex reduces endothelial inflammation. 3 year‐old female Yucatan miniature swine ran on a treadmill for 1 h, at 3.5 mph, once daily for 7 consecutive days. VCAM‐1 expression in the left common carotid artery (CCA) was determined by contrast‐enhanced ultrasound with VCAM‐1‐targeted microbubbles and immunoblot. In vivo measurement of luminal diameter changes in response to acetylcholine (10 −7 M and 10 −6 M) revealed no changes in EDD in the left CCA with Ex. Immunoblot results indicate a trend for VCAM‐1 reduction in the left CCA without associated change in eNOS protein. In brachial and femoral arteries, VCAM‐1 and eNOS expression were slightly increased while in the right coronary artery, VCAM‐1 expression was slightly decreased and eNOS expression slightly increased with Ex, although these changes were not significant. Short‐term exercise appears to have minimal effect on inflammation in peripheral conduit arteries and on EDD of the left CCA. Supported by NIH HL052490