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The consequences of maternal training and detraining in adult offspring
Author(s) -
Fernandes Leandro,
Calegare Bruno FA,
Tufik Sergio,
D'Almeida Vania
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.618.27
Subject(s) - offspring , leptin , pregnancy , adipose tissue , analysis of variance , medicine , endocrinology , insulin , biology , physiology , obesity , genetics
Growing interest has been driven by the discovery of a tight relationship between prenatal manipulations and development of short‐ and long‐term health disorders. In the current investigation we tested how swimming training (T) (8 weeks, 5 times/week, 1 h/day) of female mice before fecundation affects the metabolic profile of their offspring. We also investigated detraining (DT) effects during pregnancy in a group of animals. Three groups of pups were formed: one which T was maintained during pregnancy (TP); other which mothers were submitted to DT during pregnancy (DTP) and; a control group (C) of no trained mothers. The offspring was weighted until the 3 rd month of age, when female mice were euthanized, perigonadal adipose tissue was weighted and blood was collected to measure leptin and insulin. The results had been analyzed by ANOVA followed Tukey test (p≤0.05). Animals presented differences in body weight at the 3 rd day of life (F (2, 145)=27.72) , as well as, at post natal day 90 (F (2, 22) =9.12; DTP < DT and C). The TP group presented higher adipose tissue weight and plasma leptin levels than animals of DTP and C. Concerning insulin, a tendency of augmentation was observed on TP group. Our data suggest that physical activity or its interruption produce alterations on the intrauterine environmental which could result in long lasting offspring metabolic modifications. Support : FAPESP, CNPq and AFIP.