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Treatment with swimming and treadmill exercises reduced neuropathic pain on chronic constriction injury of sciatic nerve of rats
Author(s) -
Li Yung Tsung,
Li Zong Ying,
Hsueh Meng I,
Hung Hui Chun,
Ou Hsiu Chung,
Chen Yu Wen
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.618.15
Subject(s) - neuropathic pain , medicine , anesthesia , sciatic nerve , allodynia , hyperalgesia , treadmill , nerve injury , physical therapy , nociception , receptor
BACKGROUND Treatment of neuropathic pain is still a challenge. Pharmacotherapies provide an effective efficacy for treatment of neuropathic pain, but drugs produce some side effects. Whether exercise training without drug treatment could provide beneficial effects on neuropathic pain. MATERIALS AND METHODS Chronic constriction injury (CCI) of the sciatic nerve in male SD rats produces behavioral hypersensitivity and is an accepted model of neuropathic pain. All rats were divided into 6 groups: sham, sham with swimming/treadmill exercise, CCI, CCI with swimming/treadmill exercise. We compared behavior responses and body weight in sham operated and CCI rats with or without exercise training. Thermal hyperalgesia and tactile allodynia was assessed by Plantar test and von Frey filament test. RESULTS Our results showed that treatment with swimming and treadmill exercises attenuated thermal hyperalgesia and mechanical allodynia significantly in the CCI rat. The change trend of body weight indicated no significant differences between each group but not the sham group. CONCLUSION Our preliminary results support both swimming and treadmill exercises training attenuated neuropathic pain in the rat. This study was supported partially by a grant from the China Medical University (CMU98‐S‐35) of Taiwan.