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Effect of antigravity muscle activity on learning capacity and hippocampal protein expression in juvenile rats
Author(s) -
Oke Yoshihiko,
Kawano Fuminori,
Nomura Sachiko,
Ohira Takashi,
Fujita Ryo,
Nakai Naoya,
Ohira Yoshinobu
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.616.11
Subject(s) - juvenile , medicine , hindlimb , endocrinology , hippocampus , hippocampal formation , chemistry , biology , genetics
Effects of inhibition of antigravity muscle activity on brain function were investigated in juvenile male Wistar Hannover rats. Rats (3‐wk old) were hindlimb‐suspended (HS) for 14 days in order to remove gravitational loading in hindlimb muscles. Learning capacity was evaluated by water maze tests immediately after the termination of HS. The maze had 3‐branch points and 3 areas including starting point, platform, or blind end. In HS rats, swim path length from starting point to platform were not improved during 4 trials. Furthermore, the expression level of triosephosphate isomerase 1 (TPI1) in the hippocampus of HS rats were lower than that of cage‐control rats. TPI1 is the only glycolytic enzyme in which functional deficiency is associated to neurodegeneration. Therefore, antigravity muscle activity in growing rats might play an essential role in the learning capacity by keeping normal protein expression. This study was supported by Grant‐in‐Aid for Scientific Research S (19100009) from Japan Society for the Promotion of Sciences and Grant‐in‐Aid for Young Scientists B (21700655) from the Ministry of Education, Culture, Sports, Science and Technology.