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Oxygen Uptake Efficiency During Cardiopulmonary Exercise Testing in Healthy Subjects
Author(s) -
Sun Xingguo,
Hansen James E
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.615.4
Subject(s) - ventilation (architecture) , cardiology , medicine , perfusion , mechanical engineering , engineering
When evaluating circulatory efficiency in transporting O2 from the lung to the metabolizing tissues in normal subjects or in patients with cardiovascular disease, the relationship of oxygen uptake (VO2, mL/min, STPD) to ventilation (VE, L/min, BTPS), i.e. oxygen uptake efficiency (OUE) has been useful for heart failure prognosis. Although it has not been normalized to the variables of age, body size, gender and fitness, OUE is often reduced in patients with cardiovascular diseases and ventilation/perfusion mismatching. To better quantify and report OUE in normal subjects and patients, we considered several VO2 and VE relationships during exercise and how the above variables influenced their values. Methods and Results We studied 474 healthy adults, aged 17–78 years during increasing cycle and/or treadmill cardiopulmonary exercise at three sites, reducing the total VE by the equipment dead space ventilation. Three methods of calculation were analyzed: 1) OUE plateau (OUEP). The OUEP and OUE@AT were similar, highly reproducible, and less variable than the OUES (p<0.0001), and were unaffected by the study sites or methods of exercise. The resultant prediction equations for men are: OUEP(mL/L)=35.4–0.185xyears+0.080xcm (−2.2 for women). Conclusions The OUEP and OUE@AT are the preferred methods to measure circulatory efficiency.