Premium
Exercise‐induced flow limitation in adults with a history of bronchopulmonary dysplasia.
Author(s) -
Lovering Andrew T,
Yang Ximeng,
Laurie Steven S,
Elliott Jonathan E,
Beasley Kara M,
Hawn Jerold A,
Gladstone Igor M
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.615.3
Subject(s) - bronchopulmonary dysplasia , medicine , ventilation (architecture) , cardiology , respiratory minute volume , vo2 max , cycle ergometer , work of breathing , tidal volume , physical therapy , respiratory system , heart rate , gestational age , blood pressure , pregnancy , mechanical engineering , genetics , engineering , biology
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of infancy characterized by poor pulmonary function at term that persists into adolescence. Because exercise causes a significant increase in ventilation, we hypothesized that adults with a history of BPD would be susceptible to flow limitation during exercise at relatively low metabolic rates. Resting pulmonary function and maximal oxygen consumption (VO2max) on a cycle ergometer were determined in six subjects (1 female) born preterm (≤32 weeks) with a documented history of BPD. On a separate day, exercise flow‐volume loops were recorded during each 4 min exercise stage at 25, 50, 75 and 90% of VO2max. Resting forced‐expiratory flow at 50% of vital capacity was 2.9(1.6) L/s, mean(SD), [57(32)], [%predicted(SD)] and VO2max was 40.2(18.2) mL/kg/min [110.8(36)]. Flow limitation (%tidal volume) occurred at rest in one subject (96); 25% of VO2Max, in 2 subjects (22.7–83.7); 50% of VO2Max, in 3 subjects (47–87); and in all subjects at 75 and 90% VO2Max,(17–87) and (58.4–92.5), respectively. Exercise‐induced flow limitation was observed in all BPD subjects at low to moderate metabolic rates. Our data suggest that because individuals with BPD are flow limited during exercise, they would likely have an increased work of breathing for a given ventilation compared to their full term counterparts who do not have flow limitation. Support: AHA SDG 2280238