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Effects of anesthetic state on properties of fast inspiratory rhythms in bilateral phrenic discharges of currarized adult rats
Author(s) -
Cohen Morton I.,
Ono Kenichi,
Granata Antonio R.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.614.1
Subject(s) - phrenic nerve , anesthetic , rhythm , anesthesia , chemistry , coherence (philosophical gambling strategy) , respiratory system , medicine , physics , quantum mechanics
In both cat and rat, fast rhythms during inspiration are seen in bilateral phrenic nerve discharges. These oscillations have been classified into two types: (a) high‐frequency (HFO), present in both autospectra and in cross‐spectra (coherences) of a signal pair; (b) medium frequency (MFO), present only in autospectra of a signal pair. To analyze these effects in rats, we recorded from bilateral phrenic discharges in two types of curarized rat preparation (male Sprague‐Dawley, 280–350 gm): 1) Urethane‐anesthetized (1.8 gm/kg). In 18 rats, the opposite phrenic nerves had similar autospectral dominant peaks (distribution: 55 mean + 13 SD Hz); but there was no significant coherence between opposite phrenic discharges at this dominant frequency. 2) Supracollicularly decerebrated. In 3 rats, phrenic discharges exhibited fast rhythms (HFO, high‐frequency oscillations, range 132 –170 Hz) that were seen in the autospectra of activities on opposite sides with very similar peak frequency and which also had a significant coherence peak at the dominant frequency. The lack of significant bilateral coherence peaks under anesthesia indicates that there is a tendency to reduce the interactions between inspiratory neurons that are involved in HFO generation and suggests that such interactions are weaker between neurons on opposite sides than between neurons on the same side.(Supported by N.I.H. Grant NS‐043940.)