Premium
Inspiratory neural network complexity of unusual gasping patterns in urethane‐anesthetized neonatal rats
Author(s) -
Salay Lindsey D,
Reid Inefta M,
Solomon Irene C
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.613.2
Subject(s) - anesthesia , singlet oxygen , medicine , neuroscience , chemistry , biology , oxygen , organic chemistry
Gasping is an autoresuscitative mechanism in response to anoxia, and unusual gasp patterns ( i.e. , two or three closely spaced successive gasps termed ‘doublet’ and ‘triplet’ gasps) have been observed in infants with sudden infant death syndrome (SIDS) and non‐SIDS conditions during agonal respiration. Previously, we identified doublet and triplet gasps in spontaneously breathing urethane‐anesthetized P0‐P12 neonatal rats in response to an anoxic challenge, and characterized the timing features associated with these bursts. Here, we evaluated the complexity of the central inspiratory neural network underlying these unusual gasping patterns using approximate entropy (ApEn) analysis. For these analyses, the neonatal rats were divided into two groups based on the marked difference in the number of doublet gasps. In P0‐P6 rats (n=12), ApEn decreased from baseline (BL) when compared to singlet (from 0.318±0.008 to 0.279±0.003; P<0.01), but not doublet or triplet gasps. In contrast, in P7‐P12 rats (n=7), ApEn decreased from BL when compared to singlet (from 0.355±0.009 to 0.242±0.004; P<0.01), doublet (P<0.01), and triplet gasps (P<0.01). These data suggest that while the central inspiratory neural network underlying singlet gasps may be unaffected by developmental age, the network underlying unusual gasping patterns appears to be differentially influenced by maturation. Supported by HL63175, NS049310