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Increased Urinary Renin Excretion Rate in Chronic Ang II‐infused Rats Fed a High Salt Diet leads to augmented urinary Ang II levels.
Author(s) -
McCormack Michael,
Liu Liu,
Seth Dale M,
Kobori Hiroyuki,
Navar L Gabriel,
Prieto Minolfa C
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.605.16
Subject(s) - angiotensin ii , endocrinology , medicine , candesartan , chemistry , excretion , renin–angiotensin system , blood pressure , urinary system
This study examined the urinary excretion of renin (uRen), angiotensinogen (uAGT), and angiotensin II (uAngII) in chronic AngII‐infused Sprague‐Dawley rats fed a high salt (HS) diet. Three groups were studied: 1) AngII‐infused [80 ng/min, 14 d, n=5]; 2) AngII‐infused plus HS [Ang II+HS; 8% NaCl; n=4]; 5) AngII‐infused, HS plus an AngII type 1 receptor blocker (ARB) [Ang II+HS+Candesartan, 25 mg/L, drinking water, 14 d, n=5]. Systolic blood pressures increased in AngII (175±10 mmHg) and were augmented by HS in AngII+HS rats (222±8 mmHg). By day 13, uRen, uAGT and uAngII excretion rates increased in AngII‐infused rats, and in AngII+HS rats: [uRen (AngII: 9±3 vs. AngII+HS: 10±4 ×10‐5 Enzyme Units/day); uAGT (AngII: 1107±106 vs. AngII+HS: 4363±1673 ng/day); uAngII: (HS:1,851±327; AngII: 3,813±431; AngII+HS: 8,570±889 vs. NS: 2080±361 fmol/day; respectively)]. ARB treatment prevented these increases (uRen: 5±3×10‐5 Enzyme Units/day; uAGT: 240±28 ng/day; uAngII: 3,796±1,059 fmol/day). Thus, HS exacerbates the increases in uRen, uAGT, and uAngII as well as the systolic blood pressure in AngII‐dependent hypertensive rats. NIH [IdeA Program (P20‐RR‐017659‐06) and the Tulane‐BIRCWH Program (K12HD043451)]; and the AHA (09PRE2209079 and 09BGIA2280440).