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The dietary flavonoid quercetin decreases neuroinflammation in a mouse model of Alzheimer's disease
Author(s) -
JUNG SEUNG HO,
Murphy E. Angela,
McClellan Jamie L.,
Carmichael Martin D.,
Davis J. Mark
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.604.17
Subject(s) - neuroinflammation , quercetin , inflammation , flavonoid , placebo , medicine , pharmacology , tumor necrosis factor alpha , endocrinology , immunology , chemistry , pathology , biochemistry , alternative medicine , antioxidant
Inflammation plays a fundamental role in the pathogenesis of Alzheimer's disease (AD). The bioactive dietary flavonoid quercetin has received increased interest due to its anti‐inflammatory properties, but its effects on neuroinflammation in AD are not known. The purpose of this study was to determine the effects of dietary flavonoid quercetin on neuroinflammation in AD. Double transgenic female mice (B6C3‐Tg(APPswe, PSEN1dE9) 85Dbo/O) were randomly assigned to either quercetin (QAD) or placebo (PAD) treatments (n=10/group). C57BL/6 mice were used as age matched old (OWT) and young (YWT) controls. Quercetin (1% in mouse chow) (QAD) or placebo (OWT and PAD) was administered from 3–13 months. QAD, OWT and PAD were sacrificed at 13 months of age. YWT were sacrificed at 3 months of age. Brain tissue was collected and analyzed for TNF‐α, IL‐1β, IL‐6 and MCP‐1 mRNA expression using RT‐PCR. YWT showed significantly lower levels of TNF‐α, IL‐1β, IL‐6 and MCP‐1 versus all other groups (P<0.05). Furthermore, PAD showed significantly elevated levels of IL‐1β, IL‐6, and MCP‐1 versus OWT (P<0.05), but quercetin blunted this response for IL‐1β and MCP‐1 (P<0.05). Our data show that quercetin can partly block the increased gene expression of neuroinflammatory factors in AD. These findings may have important implications in AD as well as other neurodegenerative diseases in which inflammation plays a necessary role.