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Short term STZ‐induced diabetes reduced left ventricular dysfunction and promoted morphometric, immune and antioxidant adaptations after myocardial infarction in rats
Author(s) -
Candido Georgia Orsi,
Mendes Roberta Hack,
Rodrigues Bruno,
Rosa Kaleizu Teodoro,
Souza Leandro Ezequiel,
Di Petta Antonio,
Sammoniya Paulina,
BellóKlein Adriane,
De Angelis Kátia,
Irigoyen Maria Claudia
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.597.11
Subject(s) - myocardial infarction , medicine , ejection fraction , diabetes mellitus , superoxide dismutase , antioxidant , endocrinology , catalase , immune system , ventricular remodeling , cardiology , oxidative stress , heart failure , chemistry , immunology , biochemistry
We verified if left ventricular (LV) dysfunction induced by myocardial infarction (MI) in STZ‐diabetic rats was related to collagen deposition, inflammatory response and antioxidant enzymes profile. Male Wistar rats were divided: Control (C), Diabetes (D), MI (I) and diabetes +MI (DI). MI area was similar between I (36±6%) and DI (30±4%) groups at the end of protocol (5 days after MI surgery). However, ejection fraction (I: 38±4 vs. DI: 48±5%), fractional shortening (I: 25±2 vs. DI: 37±2%), and E/A ratio were improved in DI in comparison with I rats. Collagen (by picrosirius red stain) (25%) and myocardium inflammatory cells quantifications (by Hematoxin‐Eosin) (71%) was reduced in DI as compared with I animals; while heart antioxidants superoxide dismutase (25%) and catalase (10%) were increased in DI when compared to I rats. In addition, a positive correlation was observed between collagen and inflammatory cells quantifications (r=0.7; p<0.0001) in all groups. This study showed that the attenuation of LV dysfunction observed in DI rats is probably due to a compensatory mechanism associated with morphometric and immune adaptations, as well as an increase of antioxidant enzymes activity. These data suggest an important role of heart glucose availability in myocardial protection after an ischemic event. FAPESP