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Ursolic acid accentuates contractile and secretory functions in beating rabbit atria
Author(s) -
Cui Hao Zhen,
Choi Hye Ran,
Cho Kyung Woo,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.596.6
Subject(s) - secretion , chemistry , ursolic acid , medicine , endocrinology , biology , biochemistry , chromatography
Aim of study Ursolic acid (UA) is a well known hydroxyl pentacyclic triterpenoic acid and has been found in vegetarian foods and medicinal herbs. However, the effects of UA on cardiac functions have not well been documented. The purpose of the present study was, therefore, to address whether UA has contractile and secretory effects in perfused beating rabbit atria. Materials and Methods The UA‐induced changes in atrial mechanical dynamics, pulse pressure and stroke volume, cAMP efflux, and ANP secretion were measured in perfused beating rabbit atria. Results UA increased atrial dynamics and ANP secretion in a concentration‐dependent manner without changes in atrial cAMP levels. The UA‐induced increase in atrial dynamics was not changed by inhibition of the L‐type Ca 2+ channels and SR system. On the other hand, UA‐induced increase in ANP secretion was attenuated by inhibition of L‐type Ca 2+ channels. Conclusion These results indicate that UA accentuates atrial ANP secretion concomitantly with increase of atrial dynamics and also suggest that the accentuation of ANP secretion is related with changes in cellular Ca 2+ metabolism.